Impact of oxidative stress on muscle function


Loss of muscle mass is a well known feature in protein malnutrition and is associated with loss of function, which however occurs at an earlier stage. This implies further factors than pure loss of muscle mass to be responsible for muscle dysfunction in malnutrition. Malnutrition is associated with a lower level of antioxidants, due to reduced nutritional intake (vitamins, trace elements) and compromised synthesis of endogenous antioxidative systems (enzymes). Oxidative stress is known to induce damage to lipids, proteins and DNA. Results from animal studies have shown that muscle protein and actin amino acids are susceptible to oxidative stress and that disease related oxidative stress is increased in starvation. This study aims to investigate the extent of oxidative damage in malnourished GI patients and its association with muscle dysfunction.
Head of Project:

Dr.rer.medic. Kristina Norman
Charité - Universitätsmedizin Berlin
Department of Gastroenterology, Infectiology and Rheumatology (including workspace nutrition medicine) CCM/CBF
Department of Gastroenterology, Infectiology and Rheumatology (incl. Nutrition Medicine) CCM
Tel. 450514138
Fax 450514923
kristina.norman@charite.de
Begin/End of Project:

11/2004 - 12/2011
Funded by:

sonstige öffentliche Mittelgeber
Publications:

Ashour,MN, S I Salem, H M El Gadban, N M Elwan, T K Basu, 1999, Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo, Egypt: Eur J Clin Nutr, v. 53, p. 669-673. Dalle-Donne,I, R Rossi, D Giustarini, N Gagliano, L Lusini, A Milzani, P Di Simplicio, R Colombo, 2001, Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairment: Free Radic.Biol Med., v. 31, p. 1075-1083. Lawler,JM, C C Cline, Z Hu, J R Coast, 1997, Effect of oxidative stress and acidosis on diaphragm contractile function: Am.J.Physiol, v. 273, p. R630-R636. Rana,S, C P Sodhi, S Mehta, K Vaiphei, R Katyal, S Thakur, S K Mehta, 1996, Protein-energy malnutrition and oxidative injury in growing rats: Hum.Exp.Toxicol., v. 15, p. 810-814.