Oxidative Stress

Based on in vitro and animal studies, involvement of increased oxidative stress in the pathogenesis of diseases of the heart and circulatory system was hypothesized. However, the limited specificity and sensitivity and consequently restricted meaningfulness of the analytical methods for quantification of oxidative stress by blood testing makes it difficult to verify this hypothesis in patients. To overcome this, newly developed methods for oxidative stress analysis in blood and novel combinations of established methods directed more exactly to the study design are tested to find evidence for implication of oxidative stress in human diseases, especially in hypertension, acute and chronic coronary heart disease and heart failure.
Head of Project:

Prof. Dr. Ingolf Schimke
Charité - Universitätsmedizin Berlin
Department of Internal Medicine, Cardiology and Angiology CCM
Tel. 450-513011
Fax 450-713011
Begin/End of Project:

08/1999 - 12/2009
Funded by:


High and low response in relation to nitric oxide formation but not to lipid peroxidation in patients with sepsis. Schimke I, Richter N, Wauer H, Rohr U, Petersson A, Wennmalm A, Kruppe H, Kox WJ. Crit Car Med 2003;31:65-72. Decreased Oxidative Stress in Patients with idiopathic dilated Cardiomyopathy one year after immunoglobulin adsorption. Schimke I, Müller J, Priem F, Kruse I, Schön B, Stein J, Kunze R, Wallukat G, Hetzer R. J Am Coll Cardiol 2001;38:178-183.