Efficacy and tolerability of vagus nerve stimulation in patients with depression

Beside psychopharmacological and psychotherapeutical interventions, stimulation techniques as a novel form of antidepressant treatment are currently in development. A new approach for treatment of depression is the vagus nerv stimulation which is a surgical strategy for treatment of very resistant depressive patients. The current study is a European, multi-center trial, in which efficacy and tolerability of this novel treatment form was investigated.
Head of Project:

Prof. Dr. Malek Bajbouj
Charité - Universitätsmedizin Berlin
Department of Psychiatry and Psychotherapy CBF
Tel. +49 30 8445 8622
Fax +49 30 8445 8233
Additional Head of Project:

Prof. Heuser
Begin/End of Project:

10/2001 - 12/2008
Funded by:

ohne Fördergeber


1: Bajbouj M, Lang UE, Neu P, Heuser I. Therapeutic brain stimulation and cortical excitability in depressed patients. Am J Psychiatry. 2005 Nov;162(11):2192-3. No abstract available. PMID: 16263869 [PubMed - indexed for MEDLINE] 2: Neu P, Heuser I, Bajbouj M. Cerebral blood flow during vagus nerve stimulation--a transcranial Doppler study. Neuropsychobiology. 2005;51(4):265-8. Epub 2005 May 18. PMID: 15905632 [PubMed - indexed for MEDLINE] 3: Bajbouj M, Heuser I. [Vagus nerve stimulation, repetitive transcranial magnetic stimulation, and electroconvulsive therapy in the treatment of depressive disorders] Nervenarzt. 2005 Jan;76(1):28-35. German. PMID: 15666168 [PubMed - indexed for MEDLINE]