Development of a reference database for total lean mass with DXA, neuromuscular capacity,gait and balance parameter


OBJECTIVE: Reduced musculoskeletal capacity like muscle weakness, gait and balance deficits have been documented as major intrinsic risk factors for falls in the elderly. However, until today there is conflicting evidence on which gait and balance parameters are sensitive in predicting falls. Additionally, limited empirical evidence is available to prove the relationship between muscle mass and physical function. The aim of this study is to collect normative data concerning neuromuscular capacity, gait and balance parameters as well as lean mass values to establish parameters which are sensitive in predicting fall risks in the elderly. DESIGN: A cross-sectional, population-based study. PARTICIPANTS: A population of 780 men and women aged 20-90 years MEASUREMENTS: Physical activity level, history of fall and fractures are ascertained by questionnaires. Leg skeletal muscle mass is measured using dual-energy X-ray absorptiometry (DXA). Grip strength is used as an indicator of muscle strength. Functional performance tests including walking at different speed, Timed-up and go Test and repeated chair stands on the newly developed force plate system Gangway are used to assess lower extremity performance and dynamic postural stability. A Swaymeter is tested for its capacity to describe static postural stability.
Head of Project:

Dr. Gabriele Armbrecht
Charité - Universitätsmedizin Berlin
Department of Radiology and Nuclear Medicine CBF
Tel. +49 30 8441 5816
Fax +49 30 8441 5817
gabi.armbrecht@charite.de
Begin/End of Project:

01/2005- 12/2005
Funded by:

Universitäre Forschungsförderung Charité
Publications:

1. Feltner ME, MacRae PG, McNitt-Gray JL (1994): Quantitative gait assessment as a predictor for prospective and retrospective falls in community-dwelling older women. Arch Phys Med Rehabil 75; 447-453. 2. Lee LW, Kerrigan DC (1999): Identification of kinetic differences between fallers and non-fallers in the elderly. Am J Physical Med Rehabil 78; 242-246. 3. Visser M, Kiel DP, Langlois J, Hannan MT, Felsen DT, Wilson PW, Harris TB (1998): Muscle mass and fat mass in relation to bone mineral density in very old men and women: the Framingham Heart Study. Appl Radiat Isot;49:745-747. 4. Nevitt MC, Cummings SR, Kidd S, Black D (1989): Risk factors for recurrent non-syncopal falls: a prospective study. JAMA 261; 2663-8. 5. Maki BE, Holliday PJ, Topper AK (1994): A prospective study of postural balance and risk of falling in an ambulatory and independent elderly population. J Gerontol 49; M72-M84.