Flow in brain aneurisms as criteria for the therapy


Aneurysms are potentially life-threateningly enlargements of arteries in the brain. About 10 of 100,000 people suffer acutely by the spontaneous ruption a aneurysms every year. About 50% of them die. There are three therapy forms': the clipping, the coiling and the stenting. The decision on the therapy form depends on the knowledge of the blood flow in the aneurysm. In this project cognitions we will determine the flow conditions in realistic geometry models of characteristic brain aneurysms in numeric and experimental examinations. The geometry models are generated from CT(computed tomography) data of patients. Furthermore the differences among the therapy forms are examined.
Head of Project:

Prof. Dr. Klaus Affeld
Charité - Universitätsmedizin Berlin
Department of Cardiovascular Surgery CCM
Labor Biofluidmechanik-Forschung CVK
Tel. +49 30 450 553801
Fax +49 30 450 553938
klaus.affeld@charite.de
Begin/End of Project:

01/2003- 12/2003
Funded by:

Universitäre Forschungsförderung Charité
Publications:

Schievink WI. Intracranial aneurysms. N Engl J Med 1997; 336:28-40. Ingall TJ, Whisnant JP, Wiebers DO, O'Fallon WM. Has there been a decline in subarachnoid hemorrhage mortality? Stroke 1989; 20:718-24. Nilsson OG, Lindgren A, Stahl N, Brandt L, Saveland H. Incidence of intracerebral and subarachnoid haemorrhage in southern Sweden. J Neurol Neurosurg Psych. 2000; 69:601-7. Kolominsky-Rabas PL, Sarti C, Heuschmann PU, et al. A prospective community-based study of stroke in Germany--the Erlangen Stroke Project (ESPro): incidence and case fatality at 1, 3, and 12 months. Stroke 1998; 29:2501-6. Ingall T, Asplund K, Mähönen M, Bonita R. A multinational comparison of subarachnoid hemorrhage epidemiology in the WHO MONICA stroke study. Stroke 2000; 31:1054-61.